Epilepsy and other comorbidities in Down syndrome

Abstract Down syndrome (DS) is the most common cause of intellectual disability. Due to many genetic and biochemical aberrations, people with DS suffer from several somatic disorders concomitant diseases. Epilepsies occur more often than in normal population, but less disability other causes. have a trimodal distribution age-related phenotypes, etiologies, prognosis. The epilepsy infancy often-self-limiting West syndrome; if Lennox–Gastaut occurs later course development, seizure prognosis worsens significantly. From fourth decade life, myoclonic occurs, which combination rapidly progressive Alzheimer’s dementia life-limiting within few years.